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Acknowledgments We thank Frontiers in Molecular Biosciences for their invitation to publish our manuscript

This can be particularly beneficial for individuals who have difficulty controlling their eating habits

Description of the included studies Table 1 provides details and results of the 11 studies reviewed

The triple therapy of metformin, a DPP-4 inhibitor and a SGLT-2 inhibitor has a very low treatment related hypoglycaemia risk, leads to a further, almost additive reduction of glycaemic parameters, a body weight loss in the same range as with a mono- or dual therapy with a SGLT-2 inhibitor and also to the expected SGLT-2 inhibitor induced reduction of blood pressure