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Significant B12 deficiency can lead to anemia, nerve damage and dementia

O-GlcNAcylation of alpha-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding

The overall incidence of reported adverse reactions of hypoglycemia in patients with type 2 diabetes inadequately controlled on diet and exercise was 0.6% in patients given placebo, 0.6% in patients given sitagliptin alone, 0.8% in patients given metformin immediate-release alone, and 1.6% in patients given sitagliptin in combination with metformin immediate-release

In Hashimotos thyroiditis, selenium has been linked to decreases in anti-TPO and anti-Tg antibodies as well as slight improvements in thyroid structure and function [37,41,50]

This is not manufactured as the exact same chemical your body naturally makes