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At large concentrations, the lipophilic TPP + cation can accumulate in the mitochondrial matrix, disrupting the membrane potential and impairing organelle function

138,139 During endoscopy, biopsy samples were collected and analyzed by immunohistochemistry to quantify the expression of Ki67 (a marker of cell proliferation), as well as claudin-1 and claudin-4

The primary endpoint for this study was the number of live offspring per round of confirmed mating, which was determined by the presence of a vaginal plug as described above, and the total number of live offspring for each cohort, with n = 10 animals per group

It is the only enzyme in the GPX family that directly reduces and destroys lipid hydroperoxides

Evidence-Based Preventive Longevity Medicine