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Their simultaneous activation does not produce simple pathway redundancy but rather engages complementary aspects of the tissue repair response, providing the biological rationale for studying whether combination produces additive or synergistic repair outcomes exceeding either peptide alone

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It appears to normalize the inflammatory response, allowing necessary acute inflammation while preventing the chronic state that impairs healing

Therefore in many organs, neuropeptides can exert effects through direct innervation of the end organ (synaptic contact), but also through non-synaptic contact and paracrine activity on neighboring cells [21]