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Secondary outcomes included diagnoses of depression, mood disorder, insomnia, broadly defined cognitive deficits, nerve disorders, peripheral neuropathy, and substance-related disorders

10 th ed: Wiley-Blackwell

RYBELSUS and OZEMPIC tablets are contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) [see Contraindications (4)]

Week 5: Add MOTS-C (250mcg/day, ramp to 500mcg/day over 2 weeks) + NAD+ (250500mg/day NMN or NR)

The signal was greatest for the executive-function cognitive domain, but study limitations precluded definitive conclusions