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Focus on Heart Failure | HFpEF: Where We Stand in 2025 The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, along with the aging population and the ongoing rise in risk factors such as hypertension, diabetes and obesity

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The supply of GSH precursors from astrocytes to neurons does not only increase the GSH content in neurons but also improves the resistance of neurons to various adverse treatments, including induction of oxidative stress and application of toxins (Table 2), demonstrating the importance of the astrocytic cysteine supply for neuronal GSH synthesis

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