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The leading cause of death was identified based on the International Classification of Diseases, 10th Revision (ICD-10), including death due to cardiovascular disease (heart disease: I00-I09, I11, I13, I20-I51, and cerebrovascular disease: I60-I69), malignant neoplasms (C00-C97)

The trials included both single-dose pharmacokinetic studies and long-term treatment protocols extending up to 24 weeks

9 Anisimov SV et al