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Statements Author contributions CL, CM, TT, and RK conceived the review and led the project administration

This combination of requirements makes NMDAR a coincidence detector for coordinated presynaptic activity that supplies glutamate and postsynaptic activation that depolarizes the dendrite

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Among vasculogenic ED patients, traditional ED treatments such as selective PDE5 inhibitors, which act on the penile musculature via the NO system, often fail to elicit long-term therapeutic outcomes in subjects with severe cardiovascular and metabolic disease

PMID: 21030672 | doi:10.1152/japplphysiol.00945.2010 Zivanovic-Posilovic G et al