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Patients with type 2 diabetes and depressive symptoms received chronic candesartan administration for at least three months, which significantly improved interpersonal sensitivity and depression ratings and reset the HPA axis by reducing the sensitivity of the adrenals to ACTH and expression of AT1R (148)

Impaired BBB integrity, such as the loss or degeneration of pericytes, disturbs regional CBF, disrupting the delicate balance required for optimal neural function [4,5,6]

95% CI, 0.274 to 0.123

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