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doi:10.1038/ng.3060

Citation16,Citation46 Citation49 For example, sorbitol can accumulate in retinal and renal tissues and causes osmotic stress and cell death, Citation50,Citation51 and fructose can cause nonenzymatic protein glycation or nitration Citation52,Citation53 and contributes to pathogenesis of nonalcoholic fatty liver disease

Supporting this interpretation, fasting glucose, plasma insulin levels, and HOMA-IR were comparable between Gpr146 / and Gpr146 +/+ animals (Supplementary Fig

Intlim: integration using linear models of metabolomics and gene expression data

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