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GLP-1 secretion is stimulated by nutrient intake and exerts its effects on glucose homeostasis by stimulating insulin secretion, gastric emptying confiding the food intake, and -cell proliferation

The extensive role of GLP-1Rs and their agonists in other organs and tissues are shown in the overview in Fig

This includes the heart or the blood circulation system, but also simply all other organs and parts of the body as well, since oxygen and nutrient supply, mediated by the blood stream, are crucial for proper functioning of the organism