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There was moderate natural variation in the rates of aging-induced changes in mitochondrial NAD(P)H within the WT population, and importantly, worms that maintained a youthful mitochondrial NAD(P)H fluorescence lifetime profile into mid-adulthood were shown to have extended longevity compared to individual worms that showed earlier changes in mitochondrial NAD(P)H fluorescence

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Genetics plays a role here, and people who have genetically lower IgE levels are less likely to have chronic urticaria.[ref] Mast cells, atrial fibrillation, and cardiac diseases: Researchers estimate that there are ~50,000 mast cells/g of human heart tissue