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There are two reasons for this: (1) after its recognition by dipeptidyl-peptidase 4 (DPP-4), GLP-1 is cleaved into GLP-1(9-36) amide, which is in a low affinity

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We discuss the scientific foundations of these interventions, their clinical effectiveness, and the challenges in their implementation

According to the Rome IV criteria, such disorders can involve any combination of motility disturbance, altered mucosal and immune function, dysbiosis of gut microbiota, visceral hypersensitivity, and altered central nervous system processing (5)

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