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doi: 10.3390/ijms20061265 29 VillosladaPAlonsoCAgirrezabalIKotelnikovaEZubizarretaIPulido-ValdeolivasIet al

It does this by stimulating neurons in the central nervous system in a way that releases two neurotransmitters related to appetite: dopamine and norepinephrine

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MaciukiewiczMTiwariAKZaiCCGorbovskayaILaughlinCPNurmiELet al

The N-terminal tripeptide deletion in IGF-1 DES dramatically reduces its binding affinity for all IGFBPs by approximately 100-fold or more, while preserving or even slightly enhancing its affinity for the IGF-1 receptor itself