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Maebashi et al

In fact, compared with the separate infusion of each hormone, the combination increased both insulin response and glucagonostatic response

Muthukumar K, Rajakumar S, Sarkar MN, Nachiappan V

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Patients should be counseled about the risk of hypoglycemia, particularly if taking concomitant insulin or sulfonylureas, though tirzepatide's glucose-dependent mechanism reduces this risk compared to older diabetes medications