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AHI was found to be an independent determining factor of fasting GLP-1 levels, while DPP-4 activity was not associated with OSA parameters and severity

This finding supports the result in the feeding study operated in a 60-min interval in mice (Supplementary Fig

The results were heterogeneous: some trials, such as AMPLITUDE-O and SELECT, demonstrated significant reductions in HF-related endpoints, whereas others, like LEADER, showed only non-significant favourable trends

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Computational approaches in this domain included: Physiologically-based pharmacokinetic (PBPK) modeling Blood-brain barrier permeability prediction Metabolic stability simulation In silico toxicity assessment Drug-drug interaction prediction These computational predictions helped researchers prioritize compounds with optimal pharmacokinetic profiles before investing in expensive animal studies and clinical trials