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Furthermore, these drugs reduce deaths and sickness from heart attack and other cardiovascular outcomes by up to 20%," the White House added

[3] [4] Many patients require combination therapy to achieve optimal HbA1c targets, particularly when metformin monotherapy proves insufficient

Healthcare pros and patients need to follow key steps

Constipation may develop more gradually

Participants with normal renal function were eligible for inclusion if they were judged to be of general good health by the investigator, on the basis of a medical examination (including physical examination, medical history, vital signs and electrocardiogram [ECG]) with laboratory parameters within normal limits