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[101] Research While acute/initial nicotine intake causes activation of nicotine receptors, chronic low doses of nicotine use leads to desensitisation of nicotine receptors (due to the development of tolerance) and results in an antidepressant effect, with research showing low dose nicotine patches being an effective treatment of major depressive disorder in non-smokers., [102] However the original research concluded that: "Nicotine patches produced short-term improvement of depression with minor side effects

MRI may be preferred when optic nerve involvement or other soft tissue abnormalities are suspected

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