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Cell viability assay For cell viability assay, cells were planted in 96-well plates (34 10 3 per well) after indicated treatment, then incubated with 10% CCK-8 reagent at 37 C for 2 h

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The predominant oxylipins include AA derivatives like prostaglandins, thromboxanes, and leukotrienes (60)

Its around $15 on YesStyle, which makes it one of the most affordable brightening serums Ive seen with this kind of ingredient list

All mice were housed under a 12 h light/dark cycle, with the temperature consistently maintained between 18 C and 23 C and the humidity kept at ~50%