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[2] The reasoning behind the local designation was structural as much as functional: because the E-domain reading-frame shift alters the C-terminal sequence, the variant was predicted to interact differently with the binding proteins present in muscle interstitial spaces, keeping its action localized and its half-life short

It includes the successive oxidation and reduction of AsA and GSH with a cyclic transfer of reducing equivalents so that the plant-specific ascorbate peroxidase (APx) is able to reduce H 2 O 2 to H 2 O

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