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Mechanistically, ferroptosis is driven by the accumulation of lethal phospholipid hydroperoxides (PL-OOH), primarily derived from polyunsaturated fatty acid (PUFA)-containing phospholipids

Nguyen BC, Kochevar IE

BMI greater than or equal to 30 OR BMI greater than equal to 27 with at least one weight-related comorbidity (examples: hypertension, type 2 diabetes, dyslipidemia, metabolic syndrome, obstructive sleep apnea, osteoarthritis, metabolic dysfunction-associated steatotic liver disease)

Body composition: Maintain healthy body fat percentage

Their system yielded reproducible, functional vascularized microtissues, which supported microtumour formation and facilitated accurate anti-cancer drug screening with Food and Drug Administration (FDA)-approved compounds