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CASE 2 On june 2006, a 25-year-old mestizo Mexican male presented to the Departamento de Atencin a la Salud, Universidad Autnoma Metropolitana-Xochimilco., Mexico City, Mxico, for evaluation of an pigmented dark-brown macule localized in the right buccal mucosa with evolution time of three months

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doi:10.1016/j.amjmed.2009.03.015 Kooy A et al (2009): Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus