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In patients with mild cognitive impairment (often a precursor to Alzheimers disease), prolonged melatonin supplementation reportedly slowed the progression of cognitive decline and improved sleep and mood, though larger trials are needed

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Magnesium : Required for over 300 enzymatic reactions, including many involved in detoxification

Common therapeutic supplements include vitamin D (crucial for immune tolerance), omega-3 fatty acids (modulate inflammatory signaling), glutathione precursors (support detoxification), zinc (supports gut barrier repair), quercetin (modulates mast cell activity), and specific probiotics selected to support immune regulation