Most common side effects (12mg dose, across TRIUMPH-4 and TRIUMPH-1): Nausea: 43% TRIUMPH-4 / ~38% TRIUMPH-1 (mostly during dose escalation) Diarrhea: 33% / ~28% (peaks weeks 48, improves by week 16) Dysesthesia: 20.9% (tingling sensations onset variable, long-term persistence unknown) Vomiting: 21% / ~25% (decreases after month 3) Constipation: 25% Discontinuation rates: 18.2% in TRIUMPH-4 (osteoarthritis population), 11.3% in TRIUMPH-1 (general obesity population)
Featured Experts Amanda Kahn, MD is a board-certified internist and longevity expert in New York Andrea Traina, Pharm D, is an obesity director at Novo Nordisk Eduardo Grunvald, MD is a board-certified internist and obesity medicine specialist in San Diego, CA The Gut Hormone That Almost Didnt Make It In the 1980s and 1990s, researchers were trying to understand how the body regulates blood sugar after meals
Available from: Tola EN, Krolu N, Ergin M, Oral HB, Turgut A, Erel
Vallerga CLF, Zhang J, Fowdar, et al
Marklund, S
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