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Results from an initial optimization experiment involving 6 amino acid couplings suggested that the ideal conditions for a 25 mmol wash-free synthesis should be (i) 2.5% pyrrolidine concentration in the reaction vessel, (ii) 10 min at 90 C deprotection and 5 min at 80 C coupling, and (iii) 85 L/min nitrogen pressure of directed headspace flushing during each deprotection
NAION typically causes sudden vision loss in one eye, according to Brigham and Womens Hospital
Most patients experience significant weight loss by the three-month mark
Inform your doctor if you are pregnant, breastfeeding, or have any heart or kidney problems