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In the 1990s and 2000s, further non-RCT studies in the elderly with or without dementia/AD and low B12 status have also mostly shown no benefit of B12 for cognitive function

Mayo Clin Proc Innov Qual Outcomes

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Individuals with a personal history of acnewhether during adolescence or adulthoodmay theoretically be more susceptible, as their skin may already have a propensity towards follicular inflammation and altered sebaceous gland activity

The SURMOUNT-1 trial enrolled over 2,500 participants and tested three dose levels against placebo over 72 weeks