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conducted a screen of 189,290 small molecules for their ability to inhibit the growth of human lung adenocarcinoma (LUAD) cell lines and described four compounds known as Lung Cancer Screen (LCS) 1 to 4 with certain favorable characteristics, including low molecular weight, the capability to readily cross the cell membrane, and a confirmed ability to inhibit the growth of LUADbut not normal lung cells at a low half-maximal inhibitory concentration (IC 50 ) (10)

The first dose was given on day 0

2014 Aug 1;30(2):24452

This aggressive first-pass effect leaves very little intact NAC to circulate systemically to the brain or peripheral muscles