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After 6 months, methylmalonic acid (MMA) levels, the most specific marker for B12 activity of a food or supplement, went from 164 nmol/l to 169 nmol/l which is essentially no change and by itself would indicate no benefit of the multivitamin

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In one controlled series, twelve weekly injections produced statistically significant lightening on protected skin areas in over a third of participants, with minimal side-effects

References 1.Da Silva LE, de Oliveira MP, da Silva MR, Abel JS, Tartari G, de Aguiar da Costa M, et al

& Chaykin, S