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Human evidence remains limited and primarily cosmetic

ABCG2 is also expressed along with GLUT9 in brain capillaries and epithelial cells of the choroid plexus in mouse brain 43 and in human brain microvessels 44

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Antimalarials, fever, age (of the RBC), other drugs, and a host of other things increase oxidative stress in RBCs (which results in the production of H 2 O 2 .) The line you point out as a problem is a bit confusing, but it is entirely correct

Nuclear factor E2-related factor 2 (Nrf2), a key transcription factor and endogenous antioxidant, maintains cellular metabolic homeostasis, redox state, and protein homeostasis