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Furthermore, PINK1/Parkin mediates PARIS degradation through ubiquitylation, which in turn is involved in the regulation of mitochondrial biogenesis (Lee H

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Depending on your history, your clinician may consider: A neurologic exam (strength, reflexes, sensation, gait) Diabetes metrics if you have diabetes (A1c, glucose trends, medication review) Targeted labs for potential contributors, which may include B12, folate, thiamine, vitamin D, magnesium, iron studies, and a general metabolic panel to assess electrolytes and kidney function A review of other medications and supplements If symptoms are localized (for example, one hand), evaluation may focus more on compression neuropathies