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5.2 The guts role in mediating sleep and redox balance during aging The gastrointestinal tract has long been studied within the context of aging and exhibits multiple hallmarks of physiological decline, including altered microbial colonization, elevated low-grade inflammation, compromised barrier integrity, and reduced absorptive capacity

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(1) Vladimir N Anisimov, Vladimir Kh Khavinson, Irina G Popovich, Mark A Zabezhinski, et al (2003) Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice Biogerontology, 2003, Volume 4 (Issue 4), Pages 193-202