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Other recognised contributors to RLS include chronic kidney disease (particularly uraemia), pregnancy, and certain medications such as some antidepressants (SSRIs/SNRIs), antipsychotics, and dopamine antagonists (including anti-nausea medications like metoclopramide)

Largely yes

Here's what you're fighting against when you leave a peptide unrefrigerated: Oxidation: Exposure to oxygen can alter the amino acid residues, particularly methionine and cysteine

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Going from 2 mg directly to 8 mg, or from 4 mg to 12 mg, dramatically increases the risk of severe gastrointestinal events and potential complications