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We selected nicotine consumption-related (include age of smoking, cigarettes per day, smoking cessation, smoking initiation), genetic variation related to coffee consumption and alcohol consumption as instrumental variables related to exposure factors, clozapine concentration, norclozapine and the ratio of the two as outcome variables

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Since most of us dont have access to professional fit testing (required for respirator use in medical settings), the best we can do to ensure a fit is to conduct a seal check