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The number of cigarettes smoked daily by male smokers is 1.196 times that of females (95% CI: 1.0511.39)
The strongest design would follow an entire population of youth beginning at an age at which risk of use of any product is negligible (e.g., 10 years old) and investigate time-varying associations between e-cigarette ever use and later combustible tobacco cigarette use at multiple developmental stages throughout the entire period of risk (e.g., up until age 29), while using multiple methods to establish temporal precedence of vaping relative to smoking
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