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The CRISPR/Cas9 system has gained widespread attention among the various genome-editing methods

For more pronounced changes, such as significant skin brightening and the fading of hyperpigmentation, consistent treatment over three to six months is often required

Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis

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On the other hand, suppressing ferroptosis might enhance an M2 phenotype that is anti-inflammatory, which may help decrease tissue damage and inflammation ( Depletion of glutathione peroxidase 4 (GPX4), an enzyme that lowers lipid hydroperoxides and inhibits lipid peroxidation, is the main cause of ferroptosis in macrophages (60)