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Favourable changes in cardiometabolic markers were also reported in the Phase 2 trial data, including reductions in: Systolic blood pressure Triglyceride levels Waist circumference (a proxy for visceral adiposity) However, these are surrogate markers and should not be interpreted as evidence of a reduction in major adverse cardiovascular events (MACE)

(Sleep apnea, by the way, is a big one: Starting at perimenopause, a womans risk of sleep apnea increases by four percent every year

Lower doses reduce GI side effects

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[6]-Shogaol inhibits the production of proinflammatory cytokines via regulation of NF-B and phosphorylation of JNK in HMC-1 cells