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In theory, and as reported in many preclinical studies, the secondary TBI pathogenesis should be amenable to mitochondria-targeted pharmacological interventions resulting in improved outcomes [22]

Indeed, GSTM1 inhibits the activity of the upstream regulator of JNK, the protein kinase ASK1

J Vis Exp (138):58129 Rentschler KM et al (2021) Prenatal kynurenine elevation elicits sex-dependent changes in sleep and arousal during adulthood: implications for psychotic disorders