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HbA1c lowering effect The results of the clinical trials demonstrated significantly greater reductions in A1C with liraglutide compared to exenatide, and both GLP-1 receptor agonists caused greater reductions than those observed with sitagliptin [7] Data regarding these four agents from published head-to-head studies suggest that Liraglutide may have the largest A1C lowering capability, followed by dulaglutide, exenatide once weekly and then exenatide twice daily ( Figure 5 ) [8-10] GLP-1 RA are associated with an A1c reduction of 0.5-1.5% which is greater than 0.5-1% from DPP4 inhibitors the in head to head Duration clinical trials [11]
& Lindemans, J
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10.1002/path.5489 81 PallanteP.MalapelleU.NacchioM.SgarigliaR.GalatiD.CapitelliL.et al (2021)
Clin Chim Acta 318:5161 Berardi S, Stieger B, Hagenbuch B, Carafoli E, Krahenbuhl S (2000) Characterization of l-carnitine transport into rat skeletal muscle plasma membrane vesicles
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