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The buccal route has always been the most advantageous route for nicotine administration since the drug can reach the systemic circulation without being degraded by gastrointestinal and hepatic first-pass metabolism (56,57)
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The limited availability of historical constituent weighting data across regions also restricts the scope of our analysis, making it less applicable to other indices or time periods
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Unlike with many public health challenges, for tobacco we have the solution: exclude the tobacco industry from public health policy making and phase out the sale of commercial combustible tobacco
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