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Neurology 75, 10551061

The figure connects the activation of GLP-1R to downstream pathways (cAMP/PKA, Epac/PI3K/Akt, AMPK/SIRT1, ERK/MAPK) that regulate mitochondrial function, autophagy, proteostasis, and stress response, all of which collectively influence the hallmarks of aging to improve both cellular and systemic resilience

For significant abdominal folds, severe lower-face descent or redundant arm skin, surgery may be more effective

Its share price has fallen by 50% in 2025

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