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The most recent comprehensive synthesis is a July 2025 systematic review in the HSS Journal , the musculoskeletal journal of the Hospital for Special Surgery in New York, led by Nikhil Vasireddi at Case Western Reserve University School of Medicine

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However, when someone has type 4 hemochromatosis (which is more common than the other types), it affects ferroportin function, and excess iron can accumulate in tissues

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