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A number of currently available ferroptosis modulators also face limitations in drug-like properties, such as poor water solubility, instability and suboptimal pharmacokinetics, which hinder their development into clinically viable agents (141)

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(PubMed) El-Gharbawy A, Vockley J

Betaine supplementation has been used for over 40 years to support individuals with genetic defects of folate dependent remethylation because betaine is known to increase methionine concentration and aid homocysteine reduction