The dose was increased weekly by another 21mg patch unless participants reported adverse effects or did not wish to increase the dose, up to a maximum of four patches totalling 84mg/day
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Did they measure cotinine or another objective exposure biomarker
J Appl Stat
[PMC free article: PMC3666976] [PubMed: 23680508] Klesges RC, DeBon M, Vander Weg MW, Haddock CK, Lando HA, Relyea GE, Peterson AL, Talcott GW