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Chen BT, Avshalumov MV, Rice ME

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Moreover, artesunate inhibits appendage ligation and puncture-induced NF-B activation in lung tissue and decreases the mRNA and protein levels of COX-2 and iNOS ( 5.1.2 Antioxidant potential Extensive results carried out show that artesunate and dihydroartemisinin ameliorate oxidative stress in hyperoxia-induced and lipopolysaccharides (LPS)-induced lung injury in a dose-dependent manner, these compounds may increase nuclearrespiratoty factor 2 (Nrf2) levels in reactive oxygen species (ROS)-sensitive cells