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These hormones are part of the gut-brain axis, and their respective receptors are often present in the periphery as well as in the brain. Elucidating the pathways and processes through which GLP-1 and similar hormones modulate weight loss may allow for the finetuning and evolution of novel therapeutic interventions against obesity, which, if left unchecked, is expected to impact more than half the worlds human population by 2035

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No increase in major cardiovascular events has been reported

Additionally, BER prevents the activation of the LRR, NACHT, and PYD domain-containing protein 3 (NLRP3) inflammasome during PD-related inflammation and restores autophagy activity that safeguards dopamine neurons [24]