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Treating true deficiency can improve deficiency-related symptoms (including anemia-related fatigue and neurologic issues) (see the NIH ODS Vitamin B12 fact sheet )

Doctors must assess potential drug interactions, kidney and liver function, and conditions like pancreatitis or thyroid disease that could contraindicate use

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Another recent Although taking NMN supplements did not appear to improve sleep quality, the researchers did see improvements in overall drowsiness and muscle responsiveness in the people who received NMN in the afternoon compared with the placebo group or those who took it in the morning