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Neeland, Linge, and Birkenfeld (2024), writing in Diabetes, Obesity and Metabolism , conclude that skeletal muscle changes with GLP-1 receptor agonist treatment appear adaptive: reductions in muscle volume are commensurate with what is expected given aging, disease status, and weight loss achieved, and improvements in insulin sensitivity and muscle fat infiltration likely contribute to improved muscle quality
13 HooijmansCRRoversMMde VriesRBMLeenaarsMRitskes-HoitingaMLangendamMW
At the same time, the large number of obese patients preferred its use
Most of these new drugs are still likely several years away from approval
People with a BMI below 27 need further clinical evaluation to determine if a GLP-1 medication is appropriate for them
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