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In addition, low oestrogen status may reduce endogenous conversion of phosphatidycholine to choline (as reviewed by Derbyshire, 2019) suggesting that the menopause is a time when women experience a rapid change to the enzymatic control of endogenous choline production

Definitions for use in a multicenter clinical trial

Tamoxifen is the prototypical SERM that has both agonistic and antagonistic effects depending on the tissue, for example in breast tissue, tamoxifen exhibits an antagonistic effect [7]

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Additionally, B12 plays a role in collagen production, which is essential for maintaining the skins elasticity and reducing the appearance of wrinkles and fine lines