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Figure 4 Considering that chronic beta-cell GLP-1R signaling activates cAMP-responsive element binding (CREB) and epidermal growth factor receptor (EGFR) pathways that induce pro-survival and anti-apoptotic responses (9294), in addition to the acute potentiation of GSIS, the activation of alpha-cell GLP-1 production may also serve to promote the survival and proliferation of the remaining beta-cells ( Figure 4 )

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( PMID: 15504997 ) Buse J, Montanya E, Sesti G et al (2010) The incidence of antibody formation and the levels of antibodies are lower with liraglutide than exenatide in a head-to-head comparison

Clinical and experimental evidence has accumulated that females in humans and other mammals have higher GSH levels than males, caused by higher levels of estradiol

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