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While most evidence doesnt suggest dramatic loss of muscle or bone from GLP-1s alone, keeping tabs on strength, mass, and nutritional status can help ensure your body composition and overall wellness remain supported long-term

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In this regard, GLP-1R agonists (i.e., exenatide) improve insulin resistance suppressing pro-inflammatory phenotypes of monocytes/macrophages, and directly modulating NF-B activation and IL-1, IL-6, and TNF- expression (Yu et al., 2019)